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Determine three Goal indications of inflammation (hs-CRP, MRI SPARCC SIJ, MRI Berlin spine) at 7 days fifty two. Randomised established. Exploratory endpoints. aGeometric necessarily mean and geometric CV (%). bSPARCC SIJ and Berlin backbone scores reported for only sufferers in MRI substudies. MRI SPARCC SIJ inflammation scores range between 0 to seventy two; lower scores reveal much less SIJ inflammation and damaging adjustments symbolize improvements. MRI Berlin spine rating ranges from 0 to 69; decrease scores point out much less spinal inflammation and unfavorable adjustments signify improvements; p value to the comparison of BKZ to PBO was calculated utilizing ANCOVA with therapy, area, MRI/CRP classification (BE MOBILE one only), prior TNFi publicity (BE MOBILE two only) as preset results and baseline scores as covariate; p values without any multiplicity adjustment are indicated as nominal p values and should not be made use of being an indicator of statistical importance.
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